Injectables, cosmetics, fragrance

Many drugs dissolve poorly in water, making them hard to formulate and often forcing chemical modification such as prodrugs or salt formation. BigBasin works toward turning poorly soluble drugs into stable aqueous dispersions through colloidalization and dispersion, without altering the molecule. We choose carriers, including biodegradable polymers such as PLA, to fit the goal, meeting particle-size, stability, and safety requirements step by step, with injectable formulations as the ultimate target.

Actives such as retinol and vitamin C derivatives are sensitive to light and oxygen, and they readily oxidize and lose potency inside a formulation. BigBasin's dispersion and encapsulation technology forms these actives into a stable colloid, shields them from the surrounding environment, and releases them at a controlled rate in use. This improves both formulation stability and the delivery efficiency of the active.

For fragrance, the value lies in how long and how a scent unfolds. Encapsulating highly volatile aroma molecules in nanoparticles can temper the initial burst and modulate release over time, improving longevity. We work toward shaping the release curve, from top note to base note, by tuning the encapsulation structure.