Colloid & dispersion platform

BigBasin's technology comes down to colloidalization and dispersion: diagnose a substance's solubility behavior, turn it into a stable colloid without altering the molecule, and aim ultimately at injectable dispersions.

The platform in three steps

1. 01

   Solubility diagnosis & interface design

   We assess a substance's hydrophobicity and hydrophilicity, then design a dispersion strategy.

   We evaluate the molecule's lipophilicity, hydrophilicity, surface properties, and aggregation behavior, then design which carrier and interfacial structure will form a stable colloid. The principle is to leave the molecule chemically unchanged.

2. 02

   Colloidalization & nanodispersion

   We disperse hydrophobic substances stably in water, and implement the reverse direction too.

   By combining interfacial agents, carriers, and particle processes, we turn poorly soluble substances into uniform colloids. Biodegradable polymers such as PLA are one of the available carriers; we choose materials to fit the goal. Particle size and distribution are controlled through process variables such as nanoprecipitation and solvent evaporation.

3. 03

   Stable dispersion & injectable form

   We build dispersions that stay stable without aggregation, targeting injectable formulations as the ultimate goal.

   Formulations are designed to stay stable through storage and use. Ultimately we target injectable forms of poorly soluble drugs dispersed in water without molecular modification, meeting particle-size, stability, and safety requirements step by step.